P01-011 – Colchicine compliance and amyloidosis

Results In 14 of the 26 patients, FMF and amyloidosis were diagnosed at the same time with a mean delay in diagnosis of 22 ±9.2 years. In the remaining 12, there was a mean delay of 9.6±8 years from the onset to the diagnosis of FMF and 23±9.6 years from the onset to the diagnosis of amyloidosis. These patients were on colchicine for a mean of 13±7.6 years after the diagnosis of FMF. Eight were non-compliant, however 4 were compliant and recieved 1.5 mg/day of colchicine for a mean of 7.5 years (range 4-12 years) before the development of amyloidosis. One of these 4 compliant patients stopped colchicine 1 year prior to the diagnosis of amyloidosis after 12 years of treatment. Response to Colchicine was reported in 3 patients. History of amyloidosis was present in one and history of FMF in 3 of the 4 compliant patients. None had an associated disease. Two were homozygous and one was heterozygous for M694V.